31-12-2021, 03:22 PM
Think indication is getting clearer that it’s more infectious but less serious
Hopeful for a better 2022!!
<Bloomberg>
T cells, the body’s weapon against virus-infected cells, were primed enough by vaccination that they defended against omicron in separate studies from Erasmus University in the Netherlands and the University of Cape Town in South Africa.
The findings could help explain why the wave of omicron cases hasn’t so far caused a surge in mortality from South Africa to the U.S. and the U.K. Unlike antibodies, T cells can target the whole of the virus’s spike protein, which remains largely similar even in the highly mutated omicron.
Covid Deaths Fall in U.S. Even as Omicron Spread Continues
The Dutch researchers looked at 60 vaccinated health-care workers and found that while their antibody responses to omicron were lower or nonexistent compared with the beta and delta variants, T cell responses were largely unaltered, “potentially balancing the lack of neutralizing antibodies in preventing or limiting severe Covid-19.”
The study from the University of Cape Town’s Institute of Infectious Disease and Molecular Medicine looked at patients who had recovered from Covid or been vaccinated with shots from Pfizer Inc. and partner BioNTech SE or Johnson & Johnson. They found that 70% to 80% of the T cell responses they assessed held up against omicron.
Recent weeks have brought evidence that the new strain can erode vaccine protection, prompting governments to push for booster shots to raise the level of antibodies that can fight off the variant.
But immune protection has several layers. While antibodies block infection, T cells kill infected cells, preventing the virus from spreading and causing worse disease, Wendy Burgens, one of the University of Cape Town study authors, wrote on her Twitter account Virus Monologues. “They can’t prevent you from getting infected, but they can minimize the damage that comes afterwards,” she said.
T cells are white blood cells that can remember past diseases, kill virus-infected cells and rouse antibodies to marshal defenses. People infected with another coronavirus that was responsible for the SARS outbreak in 2003, for example, were found to still have a T-cell response to the disease 17 years later.
Hopeful for a better 2022!!
<Bloomberg>
T cells, the body’s weapon against virus-infected cells, were primed enough by vaccination that they defended against omicron in separate studies from Erasmus University in the Netherlands and the University of Cape Town in South Africa.
The findings could help explain why the wave of omicron cases hasn’t so far caused a surge in mortality from South Africa to the U.S. and the U.K. Unlike antibodies, T cells can target the whole of the virus’s spike protein, which remains largely similar even in the highly mutated omicron.
Covid Deaths Fall in U.S. Even as Omicron Spread Continues
The Dutch researchers looked at 60 vaccinated health-care workers and found that while their antibody responses to omicron were lower or nonexistent compared with the beta and delta variants, T cell responses were largely unaltered, “potentially balancing the lack of neutralizing antibodies in preventing or limiting severe Covid-19.”
The study from the University of Cape Town’s Institute of Infectious Disease and Molecular Medicine looked at patients who had recovered from Covid or been vaccinated with shots from Pfizer Inc. and partner BioNTech SE or Johnson & Johnson. They found that 70% to 80% of the T cell responses they assessed held up against omicron.
Recent weeks have brought evidence that the new strain can erode vaccine protection, prompting governments to push for booster shots to raise the level of antibodies that can fight off the variant.
But immune protection has several layers. While antibodies block infection, T cells kill infected cells, preventing the virus from spreading and causing worse disease, Wendy Burgens, one of the University of Cape Town study authors, wrote on her Twitter account Virus Monologues. “They can’t prevent you from getting infected, but they can minimize the damage that comes afterwards,” she said.
T cells are white blood cells that can remember past diseases, kill virus-infected cells and rouse antibodies to marshal defenses. People infected with another coronavirus that was responsible for the SARS outbreak in 2003, for example, were found to still have a T-cell response to the disease 17 years later.
(16-12-2021, 01:44 AM)specuvestor Wrote: [ -> ]Last year experts were saying more transmissible should be less potent. Turn out Delta was both and there was a third factor: period of incubation and infectiousness. Delta was about 3 days average while the original wuhan was more like 7-14 days hence you can see the policy changes as well
So far Omicron seems even more infectious but milder than Delta. Let's see more data on the period
Flattening the curve not only releases stress on the medical system but also on individual imuunity system by reducing viral load. If you meet 1 person with COVID a day is different from say meeting 5. Hence the exponentiality upwards AS WELL AS downwards.
PS it's actually quite interesting and instructive to read what we posted 18 months ago in this thread. That's how VB is useful for reflection with minimal noise.
(15-12-2021, 11:20 PM)CY09 Wrote: [ -> ]Those who know a bit of biology will know that the intention of viruses is to profligate themselves. So over time, they will evolve to milder variants while maintain their infectiousness. The Omicron variant is exhibiting such a behavior now, less deadly but more transmissive.